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Friday, July 31, 2020 | History

2 edition of 13-week subchronic toxicity studies found in the catalog.

13-week subchronic toxicity studies

National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.

13-week subchronic toxicity studies

direct blue 6, direct black 38, and direct brown 95 dyes.

by National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.

  • 149 Want to read
  • 39 Currently reading

Published by Dept. of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Cancer Institute, Division of Cancer Cause and Prevention, Carcinogenesis Testing Program in Bethesda, Md .
Written in English

    Subjects:
  • Carcinogens.,
  • Dyes and dyeing -- Toxicology.

  • Edition Notes

    Other titlesDirect blue 6, direct black 38, and direct brown 95 dyes.
    SeriesCarcinogenesis technical report series ; no. 108, DHEW publication ; no. (NIH) 78-1358, National Cancer Institute carcinogenesis technical report series -- no. 108., DHEW publication -- no. (NIH) 78-1358.
    The Physical Object
    Paginationxiv, 127 p. :
    Number of Pages127
    ID Numbers
    Open LibraryOL17536075M

    3. Subchronic inhalation toxicity studies are primarily used to derive regulatory concentrations for assessing worker risk in occupation settings. They are also used to assess human residential, transportation, and environmental risk. This guideline enables the characterization of adverse effects. The toxicity database for repeated inhalation exposure in laboratory animals consists of two week studies — one in rats (NTP, c) and one in mice (NTP, d). No chronic-duration toxicity, reproductive toxicity, or developmental toxicity studies are available.

    Toxicological Principles for the Safety Assessment of Food Ingredients - Chapter IV.C In-Utero Exposure Phase for Addition to Carcinogenicity Studies or Chronic Toxicity Studies with Rodents. gain at 50, ppm. In the dog week dietary study, a NOEL of 8, ppm was established based on reduced body weight gain. No target organs were identified in subchronic inhalation or dermal toxicity studies in rats. CHRONIC/CARCINOGENICITY: Dinotefuran technical was tested in lifetime studies with rats and mice and a one-year study with Size: 47KB.

    SUBCHRONIC: Dinotefuran technical was tested in week dietary toxicity studies in rats, mice and dogs. In the rat In the rat study, a NOEL of ppm was established, based on reduced body weight gain in females and adrenal cortical. During the period of administration, the animals were weighed and observed daily to detect any signs of toxicity. After 13 weeks, all surviving animals were investigated in the same way that was used in the subchronic toxicity study of 14 days repeated oral by: 2.


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13-week subchronic toxicity studies by National Cancer Institute (U.S.). Division of Cancer Cause and Prevention. Download PDF EPUB FB2

Get this from a library. week subchronic toxicity studies: direct blue 6, direct bl and direct brown 95 dyes. [National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.]. The week oral dose study in rats was performed to assess the general toxicity of PM in rats Toxicity studies are required when developing a new herbal drug.

This study aimed at examining the subchronic toxicity profile of PM in rats. After PM was administered orally at dosages of, and mg/kg/day to 10 animals per Cited by: 1. week subchronic toxicity study of a novel ginsenoside composition from ginseng leaves in rats Won-Ho Shin1#, *Yu Ri1#, Seon-Gil Do2, Young-Chul Lee2, Sang-Joon Park1 1Department of Histology, College of Veterinary Medicine, Kyungpook National University, Daegu.

In the previous week subchronic toxicity studies for dose-finding of HT carcinogenicity study conducted 13-week subchronic toxicity studies book a different institution, deaths and myocarditis with dilatation of ventricles and large amounts of pleural fluid were observed in male rats given diets containing %, % and % of HT (Lot No.

or ), but not in Cited by: 7. 23 rows  E. longifolia Powdered Root Treatment Was Nontoxic but Induced Pharmacological Effects Cited by: Ferric citrate has been used as a food additive for supplementation of iron. We performed a week subchronic toxicity study of ferric citrate in F rats with oral administration in the diet at concentrations of 0%, %, %, and %.

Reduction of body weight gain was noted in % males and by: 7. In conclusion, in the present week subchronic study, paprika color showed little or no significant toxicity even with 5% supplementation in the diet. Thus, the no-observed-adverse-effect level (NOAEL) was concluded to be 5% in the diet ( g/rat/day or mg/kg bw/day for male rats and g/rat/day or mg/kg bw/day for female Cited by: Get this from a library.

week subchronic toxicity studies: direct blue 6, direct bl and direct brown 95 dyes. [National Cancer Institute (U.S.).

Division of Cancer Cause and Prevention.; Carcinogenesis Testing Program (U.S.); National Institutes of Health (U.S.);]. Evaluation of Acute Week Subchronic Toxicity and Genotoxicity of the Powdered Root of Tongkat Ali (Eurycoma longifolia Jack) Ching-HaoLi, 1,2 Jiunn-WangLiao, 3 Po-LinLiao, 4,5 Wei-KuangHuang, 4 Ling-ShanTse, 4 Cheng-HuiLin, 4 Jaw-JouKang, 5 andYu-WenCheng 4.

subchronic: (sŭb″kron′ik) [ sub- + chronic ] In human health and disease, of moderate or intermediate duration. The term is imprecise; the period is usually as long as a month but less than 10% of a lifetime.

A week subchronic toxicity study of madder color in F rats Article in Food and Chemical Toxicology 46(1) February with 14 Reads How we measure 'reads'.

PM is a modified herbal formula based on Chung-Sang-Bo-Ha-Tang, which is a well-known prescription drug used for curing various inflammatory pulmonary diseases.

We previously showed that PM attenuated lung inflammation in a murine model of chronic obstructive pulmonary disease (COPD). The objective of the present study was to evaluate the chronic oral toxicity of PM in by: 1.

Correspondence: Takeshi Toyoda (E-mail: [email protected]) A week subchronic toxicity study of acetaminophen using an obese rat model Takeshi Toyoda1, Young-Man Cho 1, Jun-ichi Akagi1, Yasuko Mizuta 1, Kohei Matsushita1, Akiyoshi Nishikawa2, Katsumi Imaida3 and Kumiko Ogawa1 1Division of Pathology, National Institute of Health Sciences, Tonomachi, Kawasaki-ku.

Subchronic Toxicity studies 13 week study +/- 4 wk recovery (3 doses and control) Species - rat (10/sex/dose), dog or monkey (2/sex/dose) In-life observations (+/- ophthamology) Clinical pathology Necropsy Histopathology Chronic Toxicity studies Objectives 1.

In the present study, a subchronic toxicity study of SIC was performed in male and female F rats with oral administration in diet at concentrations of 0%, %, %, and % for 13 weeks.

No mortalities, abnormal clinical signs, and hematological changes were Cited by: 9. A subchronic toxicity study was here performed to re-evaluate toxic effects of HT in both sexes of F rats with dietary administration at concentrations of 0%, %, % and % for 13 weeks.

July Toxicological Principles for the Safety Assessment of Food Ingredients Redbook Chapter Chronic Toxicity Studies with Rodents.

Acute and week subchronic toxicity studies of hot-water extract of Cynanchi wilfordii Radix in Sprague-Dawley rats Chung-Tack Han, Du-Yeol Kim. considerations, and changing regulatory needs. The original subchronic inhalation Test Guideline (TG ) was adopted in (1).

TG has been revised to reflect the state of the science and to meet current and future regulatory needs. Subchronic inhalation toxicity studies are primarily used to derive regulatory concentrations forFile Size: KB. Subchronic (13­week) inhalation toxicity study of formaldehyde in rats.

Appl. Toxicol. 7(1)Zwart A, Woutersen RA, Wilmer JWGM, Spit BJ, and Feron VJ. Cytotoxic and adaptiveeffects in rat nasal epithelium after 3-day and week exposure to low concentrations. Gelidium elegans extract (GEE) is derived from a red alga from the Asia–Pacific region, which has antioxidant, anti-adipogenic, and anti-hyperglycemic effects.

However, detailed studies of the toxicology of GEE have not been performed. We evaluated the single oral dose toxicity of GEE in male and female Sprague-Dawley (CD) rats. GEE did not cause deaths or have toxic effects at dosages of Cited by: 1.The final Health Effects Test Guidelines are generally intended to meet testing requirements for human health impacts of chemical substances under FIFRA and TSCA.

- Combined Chronic Toxicity/Carcinogenicity Testing of Respirable Fibrous Particles (July ) Contact Us to ask a question, provide feedback, or report a problem.The subchronic inhalation toxicology of ethylene glycol monoethyl ether (EGEE) was evaluated in rats and rabbits using a week exposure regimen.

Groups of 20 rabbits (10 M, 10 F) and 30 rats (15 M, 15 F) were exposed to a vapor of 25 ppm, ppm, or ppm, 6 hr/day, 5 days/week.

The control groups received air only.